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KMID : 0379520030190010039
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한국독성학회지
2003 Volume.19 No. 1 p.39 ~ p.44
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Eye Irritation, Skin Irritation and Skin Sensitization Tests for Nonspecific Immunostimulator BARODON^{circledR}
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Jo Eun-Hye
Cho Sung-Dae
Ahn Nam-Shik
Jung Ji-Won
Yang Se-Ran
Park Joon-Suk
Nguyen Ba Tiep
Park Ki-Su
Hong In-Sun
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Abstract
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Two local irritation and skin sensitization studies of nonspecific immunostimulator, BARODON^{circledR} were carried out with New Zealand White rabbits and Hartley guinea pigs. In skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and there were no responses after treatment for 24 or 72 hours and the Primary irritation index (P.1.1.) was ’0’. And, in the eye irritation test, there were chemosis in some of rabbits. One of 3 rabbits in washing group was detected chemosis after 24 and 72 h following treatment and 2 of 6 rabbits in non-washing group were detected chemosis after 24h and 7 days following treatment. Therefore, total score is ’4’ after 24 h and ’2’ after 72 h following treatment by conforming article "some blood vessel are clearly hyperemic" . However evaluation value is non-irritant because M.O.I. (Mean ocular irritation index) score is below during the all experimental period and no significance through individuals and exposure time. In skin sensitization, the score of skin reaction was graded 1 with 0% sensitization rate. Taken together, these results indicate that BARODON^{circledR} may be non-irritant material. material.
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KEYWORD
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BARODON^{circledR}, Skin irritation, Eye irritation, Skin sensitization, Guinea pig, Rabbit
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